Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs.
نویسندگان
چکیده
Investigating the methods commonly used to evaluate in vitro cytotoxicity of novel compounds, specifically non-covalent DNA binders, identifies that these methods may not be appropriate. The level of anticancer activity depends not only on the incubation time but also on the absolute amount (number of moles) of drug compound applied, rather than the concentration.
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ورودعنوان ژورنال:
- Dalton transactions
دوره 39 11 شماره
صفحات -
تاریخ انتشار 2010